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Hi Andre, Quoting from p. 732-3 of the "Handbook of MRI Pulse Sequences" (Bernstein, King, Zhou, 2004): With EPI "the shift along the phase-encoded direction can be substantial [due to the low bandwidth in the phase-encoded direction]. Because of this, lipid suppression is almost always employed in EPI pulse sequences". cheers, -MH On Wed, 2010-10-27 at 12:44 +0200, Andre Szameitat wrote: > Dear SPMers, > we are planning an fMRI study at a remote site and they have told us > that with a TR of 2 sec we could scan either 23 slices with fat sat or > 30 slices without fat sat (1.5T Siemens Sonata). The data without fat > sat would be noisier, but otherwise fine (however, they didn't quantify > how much noisier). 7 additional slices are appealing, because we can't > easily increase the TR and need whole brain analysis. > > Does anybody have experience with this issue? Is fat saturation > standard so that it should always be used? > > Many thanks in advance, > Andre