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There is no need to reslice when you do the coregistration. Just use the coregister only option, and this will update the matrices in the headers so that SPM can then treat the images as if they are aligned. You can see the result of this with CheckReg. Note that the EPI need to be not too distorted for this to work. If they are distorted, then a rigid body transform will not bring them into good alignment with the anatomical scans. Best regards, -John On 14 October 2010 04:52, Jiang, Zhiguo <[log in to unmask]> wrote: > Dear All, > > > > Our old preprocessing practice is to coregister EPI to matchband then > normalize to MNI. We are trying to take advantage of the T1(MPRAGE). Our > plan is to register EPI to T1 then do segment on T1 (to get the _sn.mat) > ,from there we normalize the coregsitered EPI to MNI space. But the > resulting file is quite large (60 times the size of old practice). > Wondering how you guys resolve this issue? > > > > Thanks, > > > > Tony > > ________________________________ > IMPORTANT WARNING: This email (and any attachments) is only intended for the > use of the person or entity to which it is addressed, and may contain > information that is privileged and confidential. You, the recipient, are > obligated to maintain it in a safe, secure and confidential manner. > Unauthorized redisclosure or failure to maintain confidentiality may subject > you to federal and state penalties. If you are not the intended recipient, > please immediately notify us by return email, and delete this message from > your computer. >