Hi All, I am a new user of FSL and I need a bit help to set the high level analysis of my data. It is a longitudinal study. I have 7 patients acquired at t0 and t1 under 3 conditions. The illness is really aggressive and each activation map at t1 is really different from t0 one. What is the best approach for the high level analysis between Unpaired Two-Group Difference (Two-Sample Unpaired T-Test) or Paired Two-Group Difference (Two-Sample Paired T-Test) ? Thanks for any advice. Serena.