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Hi, all I am trying to build an oligomer ligand. I have obtained all the cif files for the monomers from HIC-UP. I tried to build several monomers in using coot. Then I modified the pdb file and stated the link in the pdb head (LINKR X ABC 1 Y ABC 2 X-Y). However, when using refmac to refine, it always separated the monomers and broke the bond, which I could fix it back in coot using 'real space refine zone'. I am wondering, what is the general practice to build such oligomer ligand? All suggestions are welcome. thank you! Changyi