Dear all,

 

It may be hard to tell where the truth is.

Please, see the paper enclosed associating fluvastatin with the highest risk …

 

Best regards,

 

Mike

 

Priv.-Doz. Dr. med. Michael Steiner

Medizinisches Labor Rostock

Suedring 81

D-18059 Rostock

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“Compared to hydrophilic statins, lipophilic are said to be less risky for the development of statin myopathy.”

 

I don't think this is correct. To quote from the BMJ review on statin induced myopathy (BMJ 2008; 337:a2286)

“Is the risk of myopathy equal for all statins?

In vitro and in vivo experiments suggest that lipophilic statins (for example, simvastatin, atorvastatin, lovastatin) are more likely to produce muscular effects than are relatively hydrophilic agents (such as pravastatin, rosuvastatin, and fluvastatin).  Lipophilic compounds are more likely to penetrate into muscle tissue, enhancing the potential for myotoxic effects. One small observational study showed that pravastatin was associated with a lower incidence of myopathy than was the more lipophilic simvastatin in patients who underwent cardiac transplant. Therefore, it is prudent to use a more hydrophilic agent in patients with pre-existing muscle disease.”

Best wishes

 

Ian Young

 

Prof.Ian S. Young

 

Professor of Medicine and Director of The Centre for Public Health

Queen's University Belfast

 

1st Floor ICS B Block

Royal Victoria Hospital

Grosvenor Road

Belfast

BT12 6BJ

Northern Ireland

 

tel: +44 (0) 2890 632743

fax: +44 (0) 2890 235900

email: [log in to unmask]

 

 

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