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Expression of Interest The Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, Greece, is seeking potential postdoctoral partners of any nationality for a joint grant application to fund 2-3 years research projects in the areas of structural biology and development of biophysical methods. Experimental work will be carried out at the University of Patras (http://www.upatras.gr) in collaboration with the European Synchrotron Radiation Facility (http://www.esrf.eu) and other European research institutes and pharmaceutical companies. The Research projects in this scientific direction of the laboratory correspond to the direct extension of results published during the last 6 years: • I. Margiolaki et al. Acta Cryst. D61, 423-432 (2005) & ESRF Scientific Highlights, p. 30-31 (2004) • S. Basso et al. Acta Cryst. D61, 1612-1625 (2005) • C. Besnard et al. Z. Kristallogr. Suppl. 26, 39-44 (2007) • J. P. Wright et al. Z. Kristallogr. Suppl. 26, 27-32 (2007) • I. Margiolaki et al. Z. Kristallogr. Suppl. 26, 1-13 (2007) • M. Jenner et al. J. Appl. Cryst. 40, 121-124 (2007) • I. Margiolaki & J. P. Wright. Acta Cryst. A64, 169-180 (2008) [Review article] • I. Margiolaki et al. J. Am. Chem. Soc. 129, 11865-11871 (2007) & ESRF Press Release (09/10/07): "Powders show their strength" • J. P. Wright et al. J. Appl. Cryst. 41, 329-339 (2008) & ESRF Scientific Highlights (Structural Biology), p. 61-62 (2006) • I. Collings et al. Acta Cryst. D 66, 539-548 (2010) • S. Basso et al. Acta Cryst. D66, 756-761 (2010)- Cover article • N. Papageorgiou et al. Z. Kristallogr. (EPDIC12 proceedings – to be published) • J. R. Helliwell et al. Z. Kristallogr. (EPDIC12 proceedings – to be published) The ideal postdoctoral candidate should have recently completed (or about to complete) his/her doctoral thesis in the field of X-ray crystallography, biochemistry, biophysics or biology. Knowledge of recombinant protein expression and purification is highly desirable. Possible research projects include: 1. Further development of the powder diffraction methods/ algorithms and combined use of X-ray diffraction with NMR and confocal microscopy. Establishment of an experimental platform for drug screening. 2. Investigation of protein-protein and protein-ligand interactions and dynamics via X-ray diffraction, NMR and live-cell imaging in order to identify new molecular targets related to proteins of high pharmaceutical interest (HARP, RNA emerging virus proteins) for use in antiviral and cancer-related drugs. For more information, please contact Irene Margiolaki at [log in to unmask], [log in to unmask] -- Irene Margiolaki Lecturer, Department of Biology, Section of Genetics, Cell Biology and Development, University of Patras, GR-26500, Patras, Greece Tel: +302610997408 Web site: http://www.biology.upatras.gr/index.php?option=com_content&view=category&layout=blog&id=83&Itemid=99 & Visiting Scientist, European Synchrotron Radiation Facility (ESRF), Grenoble, France