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Hi Patrick, Yes, I do serum paraoxonase (correct spelling, PON1), which is in fact an HDL-associated enzyme (£26.00 per assay if anyone is interested). Paraoxonase activity is indeed induced by organophosphate ingestion (as far as I can tell). It's activity is reduced by smoking and by poor diet (e.g. poor fresh fruit and veg ingestion, which we assess by measuring serum lutein). Doubtless there are also genetic factors at work. I could send your friend the method if he would like to see it. Regards, Nick Miller London On 2 September 2010 11:03, Walker Patrick (Guy's and St Thomas' NHS Foundation Trust) <[log in to unmask]> wrote: > Dear Mailbase, > > A colleague in India is trying to perform paroxinase enzyme (PON1) genotyping for organophosphate poisoning in a South Indian population. I was wondering if there was anyone in the UK who has any experience of this assay or is currently offering it as a service? > > Any information would be most helpful > > Kindest regards > > Patrick > > Trainee Biochemist > St. Thomas' Hospital > London > > ******************************************************************************************************************** > > This message may contain confidential information. If you are not the intended recipient please inform the > sender that you have received the message in error before deleting it. > Please do not disclose, copy or distribute information in this e-mail or take any action in reliance on its contents: > to do so is strictly prohibited and may be unlawful. > > Thank you for your co-operation. > > NHSmail is the secure email and directory service available for all NHS staff in England and Scotland > NHSmail is approved for exchanging patient data and other sensitive information with NHSmail and GSI recipients > NHSmail provides an email address for your career in the NHS and can be accessed anywhere > For more information and to find out how you can switch, visit www.connectingforhealth.nhs.uk/nhsmail > > ******************************************************************************************************************** > > ------ACB discussion List Information-------- > This is an open discussion list for the academic and clinical community working in clinical biochemistry. > Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. > ACB Web Site > http://www.acb.org.uk > Green Laboratories Work > http://www.laboratorymedicine.nhs.uk > List Archives > http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html > List Instructions (How to leave etc.) > http://www.jiscmail.ac.uk/ > ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/