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It's not generally appreciate that excessive vit a storage can occur even in patients normally thought to be unlikely to experience problem e.g. Cystic Fibrosis. Seem to remember a paper by James et al a few years back showing this. It's the reason we do retinyl ester measurements with our serum retinols dj >>> Nick Miller <[log in to unmask]> 01/07/2010 11:51 >>> Much as I defer to the wisdom of our grannies, it is a mistake to give cod liver oil except to subjects who are low in vitamin A. Co-existing with a generalised vitamin D deficiency, we appear to suffering from a generalised vitamin A excess. It is quite rare to see low serum vitamin A levels (in the adult population I deal with) but quite common to see high, and even dangerously high, levels of vitamin A. I presume this situation has developed since WWII. Vitamin A seems to be added to many manufactured foods and is present in most multi-vitamin supplements at rather high levels. The problem is exacerbated by the fact that retinol, which is an alcohol, is displaced from its hepatic storage sites by ethanol. So subjects who consume regular amounts of ethanol are also at risk from potential damage to the liver caused by de-localised retinol. So please, don't recomend people to take cod liver oil as a source of vitamin D - unless you really know what you are doing. Nick Miller London On 1 July 2010 10:21, David Brown <[log in to unmask]> wrote: > For those of you who might remember "cod liver oil and orange juice" was > given to pregnant women and children during and after World War II, and I > note that some GPs have been recommending it again > http://news.bbc.co.uk/2/hi/health/2017257.stm > http://www.timesonline.co.uk/tol/life_and_style/education/article417116.ece > > > David G Brown > Valencia > España > > > ------ACB discussion List Information-------- This is an open discussion > list for the academic and clinical community working in clinical > biochemistry. Please note, archived messages are public and can be viewed > via the internet. Views expressed are those of the individual and they are > responsible for all message content. ACB Web Site http://www.acb.org.ukGreen Laboratories Work > http://www.laboratorymedicine.nhs.uk List Archives > http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions > (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ This message may contain confidential and privileged information. If you are not the intended recipient please accept our apologies. Please do not disclose copy or distribute information in this e-mail or take any action in reliance on its contents: to do so is strictly prohibited and may be unlawful. Please inform us that this message has gone astray before deleting it. Thank you for your co-operation. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/