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Dear All, 

I have seen some recent and papers using the mode of anisotropy to distinguish between where changes in FA are due to changes in voxels containing 2 fibre bundles to 1 fibre bundle (causing an increase in the mode to more positive values)  - is this interpretation only valid in areas where one knows there are crossing fibres - how does one interpret such changes in the mode in areas where crossing fibres are less likely ?  

Thanks.

Mahinda