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Dear Christian, If I well understand your answer, the Time courses ----- Mail original ----- De: "Christian F. Beckmann" <[log in to unmask]> À: [log in to unmask] Envoyé: Vendredi 18 Juin 2010 23:40:39 Objet: Re: [FSL] Melodic ICA question Hi > do that? How the time courses are normalized in melodic ICA process? time courses are demeaned and then subjected to variance normalisation, i.e. scaled by a robust estimate of the voxel-wise residual noise std deviation to make sure that mere differences in the voxel-wise std derivations do not bias the PCA step and ICA cost function. hth Christian