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Hi, If you set your high-pass filter initially to zero, then save the design and then run "cutoffcalc" on the *.mat file, it will calculate the best highpass filter cutoff value for you. Note that you will also need to explicitly set the TR value in the cutoffcalc command if it is not 3.0 seconds (e.g. use --tr=2.0 for a TR of 2 seconds). All the best, Mark On 3 May 2010, at 09:51, Gabor Perlaki wrote: > Hi all, > > I have an experiment with 5min baseline, 2min active1, 2min > baseline, 2min active2, 2min baseline, 2min active3 and 2min > baseline. Active1, Active2 and Active3 are different stimuluses. I > know that it is a very strange design, but because of some reason we > can not repeat the active parts. I've read some suggestions for high- > pass filter in case of simple block design, but I don't know which > is the best choice for this experiment. > > > Thanks a lot, > Gabor >