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Dear Experts, I am trying to find a software to perform fMRI simulations. I set up 100 volumes each containing 18 slices with resolution of 2mmx2mm. In FSL-package, there is POSSUM available. However, there is no User Guide/Tutorial/Practical guide for POSSUM similar to that given for other FSL tools. I also tried to look for MIDAS, but the given website ( <http://www.midas-online.org/> http://www.midas-online.org/) is some crap about printers (?). I tried also to figure out POSSUM myself, so I gave simply the parameters and the supplied activation maps. However, I do not know how to set up the paradigm (control and active phases). It did not give me any failure message (I have checked the logfile), but it runs for almost a week. How can I define custom activation pattern (shape, size and amplitude)? How can I define paradigm? Or is there any useful tool for fMRI-data simulation? Thanks, Auer, Tibor M.D. Ph.D. Biomedizinische NMR Forschungs GmbH am Max-Planck Institut für Biophysikalische Chemie Am Fassberg 11 37077 Göttingen Germany Phone/Work: +49-(0)551-201-1725 Phone/Home: +49-(0)551-250-4576 Mobile: +49-(0)176-8012-7921 Mail: <mailto:[log in to unmask]> [log in to unmask]