Hi Gwenaëlle,
Thanks, with regard to PET and VBM study
I'm not sure I follow you correctly here: you've got a VBM study of controls and patients, but have only the PET scans on the patients?
Yes you are right, i have VBM results on control and patients but PET scans only from patients.
The thing you might want to do however is to use the grey matter information from the patients to see if this is a confound or if this correlates (depending on your question) with the PET parametric maps obtained in the same population.
I am not sure that i understood your suggestion, from this i understand that i can run one sample VBM on my patients using T1w and also single t-test VBM on their PET images and compare their atrophy changes as you said depending on the question we are interested in.
Thanks a lot for your kind help
venkat
________________________________
From: FSL - FMRIB's Software Library on behalf of Gwenaëlle DOUAUD
Sent: Sun 4/4/2010 2:12 PM
To: [log in to unmask]
Subject: [FSL] Re : [FSL] Single subject VBM
Hi Venkat,
1) I am wondering is it possible to do single subject VBM analysis, my advisor wants to see atrophy changes in a single patient by comparing it to a control group (10 subjects). This is a cross sectional scan. Any suggestions will be of great help.
Yes, it is possible, but you should then use all your subjects to create the template (using only two subjects, one of each population, to create an "unbiased" template would not be recommended here). For statistical considerations, see previous emails from Tom:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?A2=ind0903&L=FSL&P=R13329
https://www.jiscmail.ac.uk/cgi-bin/webadmin?A2=ind0711&L=FSL&P=R46006
2) We have PET scans only in our patient population but not in our control subjects, we did VBM analysis based on their T1W images, now we would like to compare PET information with this VBM result, is there a way to compare PET information only from patients with VBM results obtained by comparing control with patients.Again any suggestions will be of great help.
I'm not sure I follow you correctly here: you've got a VBM study of controls and patients, but have only the PET scans on the patients?
If so, I'm afraid you cannot relate the two results (only maybe in the discussion, but in any case not "methodologically"). The thing you might want to do however is to use the grey matter information from the patients to see if this is a confound or if this correlates (depending on your question) with the PET parametric maps obtained in the same population.
Hope this helps,
Gwenaëlle
Thanks
venkat
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