Hi, What are the ages of the children? A good portion of the training data are children starting from the age of 4. When you say you've used FLIRT, have you used the first_flirt script? If not, were you registering with or without skull? If so, what is it the first stage that went wrong? Is there a lot of neck in the image? Cheers, Brian > I have had trouble getting close registration of images from child > subjects to the MNI152 standard brain. Particularly, I am having issues > with the caudate and lateral ventricles. It seems the ventricle in the > standard brain is significantly larger than those in our child subjects > leading to significant misregistration and poor segmentation during FIRST. > I have tried to use -inweight with FLIRT to increase the weighting of this > region and FNIRT without success. Any suggestions or advice would be > greatly appreciated. Also, I am curious if there is capability to generate > my own standard brain and associated FIRST models? > > > Thanks, > > Rob North > > > >