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All - I am trying to intuitively understand the concept of the DEN (deformable elastic network) function for low resolution X-ray crystallography in Schroder et al. (Levitt & Brunger) recent Letter to Nature (Vol 464, 22 April 2010). Is this (conceptually anyway) analogous to an experimentally determined NOE distance restraint between some parts of a structure in an NMR refinement, except here using distance restraints from homologous structures determined at "high" resolution? I am trying to think of a way to describe it to students without the math. That may be impossible but I'd like to try! I should probably have posted this to CNSbb but I don't currently belong- sorry. Thanks Laurie Betts UNC