Hi Lynn

 

Pathology Harmony has recommended deriving an equation for calcium adjustment for specific combinations of Calcium and Albumin method. All users of the same platform type(and chemistries) should in principle be able to use the same adjustment equation. It’s proposed that the equations are normalized to a serum calcium of 2.4 mmol/L and that an adjusted calcium range of 2.2 – 2.6 may then be universally applied (summary attached)

 

As to the lower limit of albumin, adjustments are usually adequately accurate down to at least 20 g/L, but any deviation from the linear regression at the lower end should help to inform.

 

Best regards

Gethin

 

Gethin Roberts BSc., MSc., FRCPath.

Biocemegydd Clinigol Ymgynghorol/Consultant Clinical Biochemist

Ysbyty Bronglais Hospital

Bwrdd Iechyd Hywel Dda Health Board

01970 635748  WHTN (0) 1822 5784

 

 

Hello,

 

Could any of the list members tell me if they have an Albumin lower limit restriction when calculating Corrected Calcium, using the formula:

 

Ca(corrected, mmol/L) = Ca( measured, mmol/L) + {(40 – (Albumin) x 0.02}

 

We use the BCP method for measuring albumin and an Arsenazo-III dye for Calcium.

 

I would be interested in your comments as to how accurate you consider this formula to be at Albumin levels less than 25g/L and at what level an ionized Calcium would be more appropriate.

 

Acting Chief Biomedical Scientist,

Noble's Hospital,

Biochemistry Laboratory,

Pathology Dept.,

Strang,

Douglas,

Isle of Man.

IM4 4RJ

 

Tel 01624 650661

Email : [log in to unmask]

 

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