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Dear Philipp: Please correct me if I am wrong: "modulation" means that the intensity of the signal is transformed as some what more like "volume" in a certain area, thus increasing the accuracy of the VBM test. Then I think I should stick to use the modulation with my images. I understand that during the Normalize step, specifying preservation may switch on and off the modulation, thanks! Thank you again. Lin Yun -------------------------------------------------- From: "Saemann Philipp" <[log in to unmask]> Sent: Wednesday, March 31, 2010 10:13 PM To: "Lin Yun" <[log in to unmask]>; <[log in to unmask]> Subject: Re: [SPM] A practical VBM study workflow and doubts > Hello Lin, > > you could use an absolute threshold of 0.1. Just compare the resulting > mask with your initial brainmask to check, if that is (visually) about > the core voxels you want to test. > > The "m" in the filename "smwc1.nii" file name suggests that modulation > has been performed. You should check in the SPM8 manual how that step is > switched on and off. > > Best wishes, > Philipp > > Max Planck Institute of Psychiatry > NMR Research Group > Kraepelinstr. 2-10 > 80804 Munich > Mail: [log in to unmask] > Phone: 0049-89-30622-413 > >