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I'm not exactly sure what's in the script, but I'm guessing that the customised template is generated by spatially normalising all the images to one of the templates released with SPM and generating an average of all the spatially normalised images, possibly followed by 8mm FWHM spatial smoothing. Overall, it's very simple and was just a response to a common request about dealing with images with contrasts that differ from the T1w used for the templates released with SPM. Best regards, -John On Tue, 2010-03-02 at 14:10 +0000, Katelyn Norton wrote: > Hello all! > > I have been using a customized T1W template to normalise a group of 25 > older, healthy adults for my masters thesis with little to no problems thus far. > However, I have recently begun fielding criticism and rampant questioning from > my advisors on how this template was actually created and it's validity to be > true to my population. This has forced me to realize that I actually know > nothing and how this template was created aside from showing them John > Ashburner's matlab script and being unable to explain it much further. I trust > the script and it's template creation to be true to my subjects, however is > there any way I could prove this to others? > > If anyone can possibly "dumb-down" the creation of a customized template I > would be very very appreciative and my thesis would certainly benefit!! > > Thank you!!! > Katelyn > -- John Ashburner <[log in to unmask]>