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Hi, have a look at this paper. I believe it's exactly what you're looking for. Protein-protein interaction and quaternary structure. <http://www.ncbi.nlm.nih.gov/pubmed/18812015> Janin J, Bahadur RP, Chakrabarti P. Q Rev Biophys. 2008 May;41(2):133-80. Review.PMID: 18812015 http://www.ncbi.nlm.nih.gov/pubmed/18812015 best vincent Sollepura Yogesha wrote: > Dear All, > We found that our structure is having a large buried surface in its dimer interface (~18% as calculated by AREAIMOL). This dimer has not been observed in earlier studies and right now we have less data to support this strong interface formation. I am looking for some literature which provide guidelines to understand the relation of BSA or crystal contacts with oligomeric interfaces. > > Any suggestion is highly appreciated > > Thanks in advance > Yogi > > -- Vincent Chaptal Dept. of Physiology at UCLA http://www.physiology.ucla.edu/Labs/Abramson/index.html <http://www.physiology.ucla.edu/Labs/Abramson/index.html/> Phone: 1-310-206-1399 IMPORTANT WARNING: This email (and any attachments) is only intended for the use of the person or entity to which it is addressed, and may contain information that is privileged and confidential. You, the recipient, are obligated to maintain it in a safe, secure and confidential manner. Unauthorized redisclosure or failure to maintain confidentiality may subject you to federal and state penalties. If you are not the intended recipient, please immediately notify us by return email, and delete this message from your computer.