Hi Miles -
I would say a good example of that phenomenon is collagen, where
hydroxylation of the prolyl residues alows the polypeptide to adopt
its helical conformation. In that case it is the fact there is an
electronegative substituent on the prolyl ring that biases it into a
particular conformation, which is perfect for forming helices (and
doesn't involve a cofactor).
Best Regards,
Tom
--
Dr. Tom Murray-Rust
Department of Haematology
Cambridge Institute of Medical Research
Wellcome Trust/MRC Building, Hills Road
Cambridge CB2 0XY
On Thu, Mar 4, 2010 at 10:45 AM, Miles Pufall <[log in to unmask]> wrote:
> Dear All -
> Does anyone have some good examples where a post-translational modification
> has induced local structure? I'm particularly thinking of structure induced
> by the modification only and not something multi-step like a modification
> that recruits a cofactor that induces structure.
> Thanks!
> Miles
> Miles Pufall
> Postdoctoral Fellow, UC San Francisco
> 600 16th Street, Genentech Hall S-574
> San Francisco, California 94158-2517
>
>
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