On Mon, Feb 22, 2010 at 6:49 AM, amit sharma <[log in to unmask]> wrote:

Dear All,

Apologies for a non-CCP4question. I have a structure of a dimeric molecule, where the interfaces between monomers is held by a couple of tyrosine residues (per monomer)  juxtaposed with each other. The molecule exists as a dimer in solution. Are there ways/programs to show that the interaction between the tyrosine residues is not a consequence of crystal contacts. I guess the fact that the molecule occurs as a dimer in solution strongly suggests so. Also, any directions towards literature showing similar cases would be of great help.

Many thanks in advance
--
Amit Sharma
Postdoctoral Fellow,
Department of Biophysics,
Johns Hopkins University,
Baltimore,
MD21218