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Dear Amit, You might want to take a look at NOXclass webserver: http://noxclass.bioinf.mpi-inf.mpg.de/help.php Relevant paper is available at: http://www.biomedcentral.com/1471-2105/7/27 Goold Luck, Partha Sampathkumar NYSGXRC On Mon, Feb 22, 2010 at 6:49 AM, amit sharma <[log in to unmask]> wrote: > Dear All, > > Apologies for a non-CCP4question. I have a structure of a dimeric molecule, > where the interfaces between monomers is held by a couple of tyrosine > residues (per monomer) juxtaposed with each other. The molecule exists as a > dimer in solution. Are there ways/programs to show that the interaction > between the tyrosine residues is not a consequence of crystal contacts. I > guess the fact that the molecule occurs as a dimer in solution strongly > suggests so. Also, any directions towards literature showing similar cases > would be of great help. > > Many thanks in advance > -- > Amit Sharma > Postdoctoral Fellow, > Department of Biophysics, > Johns Hopkins University, > Baltimore, > MD21218 >