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On nucleation I'm not sure if there is any effect - I suspect you've got far more trouble from Brownian motion. For growth low frequency vibration (picking up the tray and putting it down) has much more influence than high-frequency (e.g. fans or motors). The liquid acts to damp most of the high-frequency effects. I would not worry about the effect of the fire alarm, just the process of putting it in! Cheers, Eddie Edward Snell Ph.D. Assistant Prof. Department of Structural Biology, SUNY Buffalo, Hauptman-Woodward Medical Research Institute 700 Ellicott Street, Buffalo, NY 14203-1102 Phone: (716) 898 8631 Fax: (716) 898 8660 Skype: eddie.snell Email: [log in to unmask] Telepathy: 42.2 GHz Heisenberg was probably here! From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Jim Pflugrath Sent: Friday, January 22, 2010 10:11 AM To: [log in to unmask] Subject: Re: [ccp4bb] question on the effect of a fire alarm on crystallization I do not know the effect myself, but the idea of "vibration fee" has been tossed around a while. I believe that no vibration reduces the amount of nucleation that one might get, thus a vibration-free environment is detrimental when screening for hits. If you already have a method to grow crystals, then I can be convinced that a vibration-free environment might be helpful. Some of my best crystals have grown after subjecting the trays to physical or thermal shock. Since those observations, I never work about vibrations or temperature control. I think about it, but I do not worry about it. ________________________________ From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Jacqueline Vitali Sent: Friday, January 22, 2010 8:14 AM To: [log in to unmask] Subject: [ccp4bb] question on the effect of a fire alarm on crystallization Dear all, Does anyone know the effect of a fire alarm placed in the same room where one grows crystals? (1) On trays placed inside styrofoam boxes (2) On trays placed inside an incubator which has not been tested as vibration free. Thank you. Jackie Vitali