Hi I think that even post-refining with high resolution data you are unlikely to refine reliably to the same value within 1 part in 10,000 if you are making small differences to your processing. The differences you have are what I would consider to be within experimental error, so I wouldn't worry about them at all. > Hi > > I was processing my data with XDS several runs, they gave slightly > different cell parameters everytime, eg: > 1) 77.100 103.850 116.550 90.00 90.00 90.00 P 21 21 21 > 2) 77.086 103.821 116.533 90.00 90.00 90.00 P 21 21 21 > > I have already a refined model from 1), can I use this model to > refine against dataset 2) by simply change the cell parameter in the > pdb file? There's nothing wrong with dataset 1), just wonder whether it > is doable . > > Many thanks > Jane >