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Hi I was processing my data with XDS several runs, they gave slightly different cell parameters everytime, eg: 1) 77.100 103.850 116.550 90.00 90.00 90.00 P 21 21 21 2) 77.086 103.821 116.533 90.00 90.00 90.00 P 21 21 21 I have already a refined model from 1), can I use this model to refine against dataset 2) by simply change the cell parameter in the pdb file? There's nothing wrong with dataset 1), just wonder whether it is doable . Many thanks Jane