Dear colleagues, We are pleased to announce that version 2.2 of the package IL MILIONE for protein crystal structure solution by X-ray crystallography is now available. It includes algorithms for: -- initial phasing by ab initio, MR, SAD/MAD, SIR/MIR, SIRAS/MIRAS techniques; -- phase refinement by dual-space interation procedures and data extrapolation (EDM & FreeLunch); -- model building and completion by a third-party package (ARP/wARP, phenix.autobuilding, etc) powered by DEA recycling. It is equipped with an help online and a user-friendly GUI to start and monitor the runs. The package may be downloaded from the link "Software" on http://www.ic.cnr.it The research group on protein crystallography of the Institute of Crystallography, CNR, Italy