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Hi Nope, by default melodic does not remove the mean time course - in the yet to be released version this is an additional command line option. hth Christian On 4 Dec 2009, at 17:52, Srinivas wrote: > Thanks Stephen. Since FSL removes mean per voxel why the need to remove > mean per time point while computing eigen vectors. > > Srinivas _______________________________________________ Christian F. Beckmann, DPhil Senior Lecturer, Clinical Neuroscience Department Division of Neuroscience and Mental Health Imperial College London, Hammersmith Campus Rm 419, Burlington Danes Bldg, Du Cane Road, London W12 0NN, UK Tel.: +44 (0)20 7594 6685 --- Fax: +44 (0)20 7594 6548 Email: [log in to unmask] http://www.imperial.ac.uk/medicine/people/c.beckmann/ Senior Research Fellow, FMRIB Centre University of Oxford JR Hospital - Oxford OX3 9DU Tel.: +44 (0)1865 222551 --- Fax: +44 (0)1865 222717 Email: [log in to unmask] http://www.fmrib.ox.ac.uk/~beckmann