Hello, The PYTHONPATH does not have to include Python's own directory, so Python knows how to find its own libraries (and those in a sub-directory of lib/python2.5 called site-packages). But PYTHONPATH does have to include the relevant CCPN path or else Python does not know how to find that. Now we could play a trick where we insert the relevant directory at start-up, but we prefer not to do it that way. So what you need is (assuming you are using bash rather than csh or tcsh): export PYTHONPATH=/Users/mp84/Work/ccpnmr/ccpnmr2.1/python Now that still might not be good enough because of Tcl/Tk. In the pre-compiled releases we set up a script (bin/analysis) which has all the environment set up. So on your Mac this script would look like (if you are using our Tcl/Tk, which I assume you are): export CCPNMR_TOP_DIR="/Users/mp84/Work/ccpnmr" export PYTHONPATH=".:${CCPNMR_TOP_DIR}/ccpnmr2.1/python" export LD_LIBRARY_PATH="/Users/mp84/Work/ccpnmr/tcl8.5/lib:/Users/mp84/Work/ccpnmr/tk8.5/lib" export DYLD_LIBRARY_PATH="/Users/mp84/Work/ccpnmr/tcl8.5/lib:/Users/mp84/Work/ccpnmr/tk8.5/lib" export TCL_LIBRARY="/Users/mp84/Work/ccpnmr/tcl8.5/lib/tcl8.5" export TK_LIBRARY="/Users/mp84/Work/ccpnmr/tk8.5/lib/tk8.5" /Users/mp84/Work/ccpnmr/python2.5/bin/python2.5 -i -O ${CCPNMR_TOP_DIR}/ccpnmr2.1/python/ccpnmr/analysis/AnalysisGui.py $* I would generally recommend this approach rather than setting the environment in .bash_profile (or wherever) because it will not pollute any other users of Python / Tcl / Tk. Wayne On Sat, 5 Dec 2009, Mark Pfuhl wrote: > I did as advised (recompiling C code with -arch i386) and at least I now get a new error > message when I run analysis: > > Error, cannot import core CCPN Python modules: > Maybe your PYTHONPATH environment variable is not set or > does not contain the current CCPN installation directory. > Traceback (most recent call last): > File "/Users/mp84/Work/ccpnmr/ccpnmr2.1/python/ccpnmr/analysis/AnalysisGui.py", line > 71, in <module> > raise ImportError > ImportError > > I started AnalysisGui.py both with the ccpn version as well as the system copy of python, > the result is the same. There is also no improvement when I set PYTHONPATH to the > python2.5 directory that comes with CCPN. > Any more suggesetions? > thanks, > mark >