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how about this for a general idea: resolution is related to order in the crystals, more order = diffraction to higher resolution the order is determined by crystal contacts, stronger crystal contacts = more order more solvent means, on average, less close packing and less crystal contacts (of course, there are cases where only a few strong crystal contacts make for a very highly ordered crystal diffracting to high resolution, so there are quite a few exceptions of high solvent content being compatible with high resolution diffraction) or is this too simplistic? (and widely known?) Mark J. van Raaij Dpto de Bioquímica, Facultad de Farmacia Universidad de Santiago 15782 Santiago de Compostela Spain http://web.usc.es/~vanraaij/ researcherID: B-3678-2009 On 10 Dec 2009, at 00:56, Jeremiah Farelli wrote: > Hello all, > > Does anyone know of some relevant literature (or a general idea > really) that > discusses protein crystal solvent content vs. average resolution? I > am > under the impression that the higher the solvent content, the lower > the > average resolution....but I'd like to see some sort of data to back > this up. > > Thanks!