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Hi all, In one of my 2.52 A structure, which is dimeric, the R-factor is 21.4 and free-R is 29.3. I have tried all ways to reduce the free-R including TLS (even by defining the number of TLS group per chain), but still factors are not getting reduced. Even i have tried some other space group, but no use. Even i have the same structure with some complex at 1.86 A in the same space group , but everything is fine in that. Any suggestion, Regards, -- Pankaj Chauhan Senior Research Fellow, Graduate student Crystallography Laboratory Division of Protein Science & Engg. IMTECH , Chandigarh, INDIA