Hi Jesper Thanks for the prompt reply. Yes your reply justifies what I thought. I was just curious anyway. Got pretty good results using FLIRT though. Thanks Truly, Indika Walimuni Research Associate University of Texas Health Science Center Houston, TX. ________________________________________ From: FSL - FMRIB's Software Library [[log in to unmask]] On Behalf Of Jesper Andersson [[log in to unmask]] Sent: Tuesday, November 17, 2009 5:44 PM To: [log in to unmask] Subject: Re: [FSL] register T1 to T2 using FNIRT Hi Indika, I am afraid that fnirt cannot be used for that. Fnirt registers T1- >T1, T2->T2 etc. It manages to handle small differences in weighting between the images through its intensity modulation, but they need to be pretty similar. Why do you need to register T1 to T2. Fnirt does between subject registration, and as long as you have one common "contrast" between the two subjects you can use that for the registration, and then apply the transform to those other contrasts. Good Luck Jesper On 17 Nov 2009, at 23:24, Indika Walimuni wrote: > Hi FSL experts > Can I use FNIRT to register a T1 weighted > image to > a T2 weighted image ? According to the FNIRT documentation, I got > the idea > that FNIRT is sensitive to deference in contrast. If I can indeed > use what > kind of intensity modulation options (cost function/s) should I use ? > Thanks in advance, > Indika Walimuni >