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Hi Armando, high R-factor at low resolution is likely to be due to poor bulk solvent model. Some relevant reading: Jiang, J.-S. & Brunger, A. T. (1994). J. Mol. Biol. 243, 100-115. "Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures." A. Fokine & A. Urzhumtsev. Acta Cryst. (2002). D58, 1387-1392. "Flat bulk-solvent model: obtaining optimal parameters" P.V. Afonine, R.W. Grosse-Kunstleve & P.D. Adams. Acta Cryst. (2005). D61, 850-855. "A robust bulk-solvent correction and anisotropic scaling procedure" Pavel. On 10/16/09 7:55 AM, Armando Albert de la Cruz wrote: > What does it mean having the R factors a high resolution lower than at > low resolution?. Could be related to the fact my model is incomplete? > Armando