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Hi, I think that SPM may view the image in a different orientation to FSLView and also probably uses a different display range for the intensities. If your "grey" in FSLView is a uniform colour across the image with no features, then this probably indicates that the display range encoded in the image was inappropriate and you need to set the values for the display range (min and max) yourself in order to see the image clearly. Try this and see if that works. I doubt that any of this has any bearing on the use of fslmerge vs 3d to 4d. I think it is just about how images are typically displayed. All the best, Mark On 13 Sep 2009, at 10:24, cliff wrote: > hello all， > when i use "fslmerge" & "3d to 4d" tool in spm5 to merge a group > of .hdr/.img file into a 4D file(.nii and .nii.gz) separately. i > find that the image result showed in “fslview” is really different. > then i find before merging into 4D file, just use “fslview” and > spm5's “display” tool to check the same .hdr/.img file, the result > is also different. the .hdr/img images showed in "fslview" are grey > while showed in spm5 are more normal as we see usually. > > any body have these experience? can you tell me why? > > -- > Best regards! > > Sen-Hua Zhu > Department of Psychology > Sun Yat-sen University > 135 Xingang West Road, Haizhu District, Guangzhou (510275), P.R.China > 朱森华 > 中山大学心理学系 > 广东省广州市海珠区新港西路135号（510275） >