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That data is probably of too poor quality for the registrations to work well. I recommend you try 2mm isotropic data, however that SNR still seems too low to me. Are you using a 1.5T magnet and/or a high b value? Peace, Matt. -----Original Message----- From: FSL - FMRIB's Software Library [mailto:[log in to unmask]] On Behalf Of Mike Yassa Sent: Friday, September 18, 2009 4:59 PM To: [log in to unmask] Subject: Re: [FSL] volume corruption Hi Matt, Attached is a picture of the pre-ECC volume. Post ECC is blank as you saw in the previous email. The sequence is 0.8 x 0.8 x 4mm coronal with 32 directions. The data's dimensions are 256 x 256 x 15 x 34. Because of the high resolution they are very noisy, but that's not the problem. Any ideas? Thanks! Mike