Could you send me a picture of the segmentation and underlying image? Cheers, Brian > Thanks Brian, > > I tried bias field correction prior to FIRST as you described. There is > some > improvement but there is still a significant amount of tissue missing. > > Best > Deniz > > On Wed, 26 Aug 2009 23:47:54 +0100, Brian Patenaude > <[log in to unmask]> wrote: > >>Hi, >> >>There is actually many children in the training set used to create the >>model. Is there any difference in presence of bias field effects between >>the adults and children? You could try running >> >>brain extracting -> bias field estimation with FAST -> apply correction >> to >>whole head image -> the run FIRST >> >>Cheers, >> >>Brian >> >>> Hi, >>> >>> I am trying to segment cerebellum using FIRST on small group of >>> subjects >>> that >>> consists of adults and children. I am really impressed by the >>> segmentation >>> that >>> I get on adults, but the segmentation on children images are >>> underestimating >>> the cerebellum by about 5 mm towards the bottom and sides. >>> >>> I was wondering if there are any parameters I can adjust, or different >>> models >>> that are available for children. >>> >>> I am using the following commands to get the segmentation. (I believe >>> somebody has posted these here a few months ago, thanks :) ). "T1" >>> refers >>> to >>> an MPRAGE sequence, it is *not* brain stripped. >>> >>> Thanks in advance for any input you can provide. >>> >>> Deniz. >>> >>> run_first_all -i T1.nii.gz -o T1_out >>> >>> first_flirt T1 T1_to_std_sub -cort >>> run_first -i T1 -t T1_to_std_sub_cort.mat -n 40 -o T1_R_Cereb -m >>> ${FSLDIR}/data/first/models_336_bin/intref_puta/R_Cereb.bmv -intref >>> ${FSLDIR}/data/first/models_336_bin/05mm/R_Puta_05mm.bmv >>> first_boundary_corr -s T1_R_Cereb -i T1 -b fast -o T1_R_Cereb_corrected >>> >>> > >