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Hi > 1- It analyzes all voxels at the same time or only one voxel to > find the independent components? > It's multi-variate, i.e. calculates components based on analyzing all voxels simultaneously. > > 2- Melodic uses ICA or PCA? I read the papers about this tool end > there have been showed PICA. I don't understanding. PICA stands for "Probabilistic Independent Component Analysis". Meldoic (and most ICA techniques) do use PCA as part of the process, though. See the original PICA paper for details. hth Christian Christian F. Beckmann, DPhil Senior Lecturer, Clinical Neuroscience Department Division of Neuroscience and Mental Health Imperial College London, Hammersmith Campus Rm 419, Burlington Danes Bldg, Du Cane Road, London W12 0NN, UK Tel.: +44 (0)20 7594 6685 --- Fax: +44 (0)20 7594 6548 Email: [log in to unmask] http://www.imperial.ac.uk/medicine/people/c.beckmann/ Senior Research Fellow, FMRIB Centre University of Oxford JR Hospital - Oxford OX3 9DU Tel.: +44 (0)1865 222551 --- Fax: +44 (0)1865 222717 Email: [log in to unmask] http://www.fmrib.ox.ac.uk/~beckmann