Dear Debajyoti
There is also the sulfenic acid species (-S-OH) which is actually
the first oxidized form of sulfhydryls on the way to sulfonic acid. However
sulfenic acids are very susceptible to further oxidation to sulfinic and sulphonic
acids, and therefore need a protective chemical environment to remain stable.
See for example some previous work of ours on sulfenic and
sulfinic forms of active-site cysteines in glutathione reductase (Nature
Structure Biology vol 5, 267-271, 1998) and the corrresponding pdb entries 1dnc
and 1gsn.
Best regards
Savvas
----
Savvas Savvides
L-ProBE, Unit for Structural Biology
Ghent University
K.L. Ledeganckstraat 35
9000 Ghent, BELGIUM
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From: CCP4 bulletin board
[mailto:[log in to unmask]] On Behalf Of Debajyoti Dutta
Sent: Wednesday, August 19, 2009 4:42 PM
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Subject: [ccp4bb] cyseteine modification
Dear Sir,
Is there any other oxidation states of cysteine other than cysteine sulphinic
acid and cysteine sulphonic acid. In my protein, the cysteine molecule is
definitely overoxidized but the electron density is not corresponding to the
sulphinic or the sulphonic acid. The positive density looks as if it can
accomodate only one oxygen atom and not more.
Thank you for reply in advance.
Sincerely
Debajyoti Dutta