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Hi Anatasia, According to the original TFCE paper, TFCE incorporates the cluster information across a range of possible cluster-forming thresholds, which makes it difficult, especially on the TBSS skeleton, to compare the results with clusters formed after thresholding the T-stat map. Could you please upload the data in order for us to take a look at it? Cheers On Tue, Jul 7, 2009 at 2:59 PM, Anastasia A Ford <[log in to unmask]>wrote: > Hello, > > I am working on TBSS/VBM comparison and was wondering whether there are any > cases where TFCE correction could fail. Examining our raw t-stat images for > both TBSS and VBM analysis, we note t-values of 5 and above distributed in > clusters that do support our hypothesis. However, once TFCE is performed, > no > group differences survive the correction. Is there a reason why this might > be happening? > > Sincerely, > > Anastasia > > -- G. Salimi-Khorshidi, D.Phil. Student, Dept. of Clinical Neurology, University of Oxford. [log in to unmask] http://www.fmrib.ox.ac.uk/~reza FMRIB Centre, John Radcliffe Hospital, Headington, Oxford, OX3 9DU Tel: +44 (0) 1865 222466 Fax: +44 (0)1865 222717