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Hi, I believe the example_func file is the middle time point from your 4D series, and this gets created automatically. If it's not in the output (i.e., <something>.ica/example_func.nii.gz), then perhaps you have another error somewhere earlier in the log? David -----Original Message----- From: FSL - FMRIB's Software Library [mailto:[log in to unmask]] On Behalf Of Lisa Eyler Sent: Tuesday, July 28, 2009 6:59 PM To: [log in to unmask] Subject: [FSL] registration problem within MELODIC Hi, I am running into problems with registration of the functionals to the high res anatomicals within MELODIC. It doesn't seem to be able to find "example_func". I assume that this is just a renamed version of this subject's functional data, but I don't know why the program cannot find it. Any guidance would be appreciated. Here's the log: Registration /bin/mkdir -p reg /brain-bin/fsl_401_20070927/centos4_32/fsl/bin/fslmaths /data/MoreProjects/ACE_Toddler_fMRI/ScanSessions/ProgRept_0609/FCAnalysis/IC A_FSL/ZARA_24608_spgr_lang_15db_brain highres /brain-bin/fsl_401_20070927/centos4_32/fsl/bin/flirt -ref highres -in example_func -out example_func2highres -omat example_func2highres.mat -cost corratio -dof 12 -searchrx -90 90 -searchry -90 90 -searchrz -90 90 -interp trilinear ** ERROR (nifti_image_read): failed to find header file for 'example_func' ** ERROR: nifti_image_open(example_func): bad header info Error: failed to open file example_func ERROR: Could not open image example_func Image Exception : #22 :: Failed to read volume example_func terminate called after throwing an instance of 'RBD_COMMON::BaseException'