In general, you need run it with data processed in the "correct" space group (in your case, P3n).  [If all original indices are unmerged but with a wrong SG, it may also be OK when you know how to deal with.]

On Jul 9, 2009, at 1:14 PM, Laurie Betts wrote:

I have a P62 crystal that is probably p31 (or P32).  When I run the detwin program to actually output detwinned data,
do I input the mtz as processed (e.g. as output from dtrek or HKL2000) in the wrong (higher symmetry) or
the correct space group - Thanks




Laurie Betts
University of Pittsburgh
X-ray Crystallography Facility Manager
Department of Structural Biology
3501 Fifth Avenue,
Pittsburgh, PA 15260
412-383-5839
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Lijun Liu, PhD
Institute of Molecular Biology
Department of Physics
University of Oregon
Eugene, OR 97403
541-346-5176
http://www.uoregon.edu/~liulj/