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Dear all, We have thought about this for a while, and feel that urinary MMA is a good marker. Unfortunately, the 'usual' MMA assays are set up to measure MMA in methylmalonic aciduria patients so may not be sensitive enough for use in Vit B12 deficiency. So we have set up another assay - specifically for use in B12 deficiency investigation here at Sheffield Children's Hospital. We require ~5mL of urine - no need to acidify. Hope this helps, Roy. Dr R Talbot. Clinical Biochemist, Department of Clinical Chemistry, Sheffield Children's Hospital, Western Bank, Sheffield. S10 2TH. >>> Joseph WATINE <[log in to unmask]> 21/7/09 13:41:09 >>> In France, I would rather advise MMA rather than homocysteine measurements because, as far as I know, only MMA measurements are being reimbursed here. Best regards, Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem Laboratoire de Biologie Polyvalente Centre Hospitalier Général 12027 Rodez Cedex 9 France > Date: Tue, 21 Jul 2009 13:09:58 +0100 > From: [log in to unmask] > Subject: markers for Vit B12 deficiency > To: [log in to unmask] > > Dear all, > > > Methyl malonic acid and homocysteine are both markers for B12 deficiency. Is there any evidence that we need to measure both? Is one test better than the other? Should MMA be measured in plasma or urine? > > Any advice greatly appreciated. > > Thanks, > > Wolf > > > Wolf Woltersdorf MD MRCP FRCPath > Consultant Senior Lecturer and Chemical Pathologist > Head of U-STAR Research > University Hospitals Bristol > BS2 8HW UK > Tel: (+44) 0117-342 3245 > Fax: (+44) 0117-342 3107 ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/