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Dear Michael - The manual by Rik Henson might help as an entry point: http://www.fil.ion.ucl.ac.uk/spm/data/#con hth, Claus -----Original Message----- From: SPM (Statistical Parametric Mapping) [mailto:[log in to unmask]] On Behalf Of Michael Froelich Sent: Dienstag, 2. Juni 2009 19:02 To: [log in to unmask] Subject: [SPM] 2nd Level analysis Help Hi SPMers, I have set up a first level analysis for several subjects and want to enter them into a random effects, 2nd level analysis. I have studied the SPM manual and learned that the 'Speficy 2nd-level' module is intended for that purpose. But now I have come up with more questions than answers. For example: There are entries for a One-sample t-test. What if I had both t-tests and F-tests in my first level analysis? What 'Scans' do I enter? Is this referring to '.con' images, '.ess'-matrices, original scans? If anyone can refer me to a powerpoint presentation or document that would cover the 2nd- level analysis (random effects) of fMRI data, I'd appreciate it. Michael Froelich