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This is a known old bug.  update your SPM installation.

-----
Darren Gitelman, MD
sent from my iPhone

On Jun 4, 2009, at 6:50 AM, Richard Binney  
<[log in to unmask]> wrote:

> Hi,
>
> I have previously run FMRI anlyses and not had any such problems,  
> but during my latest analysis SPM5 is behaving strangely.
>
> I'm currently specifying and estimating at the the first level  
> (fixed single subject level).  When reviewing the design matrices  
> follwioing specification, everything looked fine.  However, after  
> estimation a few things have gone wrong:
>
> 1) Having previously estimated about 13 datasets, I specfied and  
> estimated 4 newly acquired datasets.  2 strange things occurred: a)  
> the SPM.mat file of a previously estimated dataset was overwritten  
> so that in 'review' this SPM.mat file showed the design matrix (and  
> associated images) of one of the newly estimated datasets; and b)  
> the design matrix of some datasets exhibited a grey colour in the  
> column for the constant while the majority were pure white as I  
> would expect.  In other cases this column had soft grating (see  
> attached image).  This was despite the fact that each particpant's  
> design was specified using the exact same batch file.
>
> 2) In response to this, and to check it wasn't an error on my part  
> (e.g. mixing file associations), I deleted all the first level  
> analyses and completely re-specified and re-estimated all the  
> datasets.  While the SPM.mat files seemed to have the correct  
> associated files, the variance in the colour of the constant column  
> (which was always pure white prior to estimation) got more severe  
> than before.
>
> 3) I have also previously attempted to run two different group-level  
> (random effects) analyses with this data  a onesample t-test and a  
> two sample t-test.  This had a similar effect of mixing up  
> associated SPM.mat and individual contrast files.
>
> Can anyone tell me what is normal, what is not and what might be  
> going on?
>
> HELP!!
>
> Thanks
>
> Richard
> <strangedesignmatrix.jpg>