This is a known old bug. update your SPM installation. ----- Darren Gitelman, MD sent from my iPhone On Jun 4, 2009, at 6:50 AM, Richard Binney <[log in to unmask]> wrote: > Hi, > > I have previously run FMRI anlyses and not had any such problems, > but during my latest analysis SPM5 is behaving strangely. > > I'm currently specifying and estimating at the the first level > (fixed single subject level). When reviewing the design matrices > follwioing specification, everything looked fine. However, after > estimation a few things have gone wrong: > > 1) Having previously estimated about 13 datasets, I specfied and > estimated 4 newly acquired datasets. 2 strange things occurred: a) > the SPM.mat file of a previously estimated dataset was overwritten > so that in 'review' this SPM.mat file showed the design matrix (and > associated images) of one of the newly estimated datasets; and b) > the design matrix of some datasets exhibited a grey colour in the > column for the constant while the majority were pure white as I > would expect. In other cases this column had soft grating (see > attached image). This was despite the fact that each particpant's > design was specified using the exact same batch file. > > 2) In response to this, and to check it wasn't an error on my part > (e.g. mixing file associations), I deleted all the first level > analyses and completely re-specified and re-estimated all the > datasets. While the SPM.mat files seemed to have the correct > associated files, the variance in the colour of the constant column > (which was always pure white prior to estimation) got more severe > than before. > > 3) I have also previously attempted to run two different group-level > (random effects) analyses with this data a onesample t-test and a > two sample t-test. This had a similar effect of mixing up > associated SPM.mat and individual contrast files. > > Can anyone tell me what is normal, what is not and what might be > going on? > > HELP!! > > Thanks > > Richard > <strangedesignmatrix.jpg>