Thank you Brian,
Does this mean that vit D decreases in inflammation in a way that is independent from any nutritional problem?
What can the extent of such decreases be? 10% of basal vit D values? 20%? 30%? more?
Best regards,
Joseph
Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem
Laboratoire de Biologie Polyvalente
Centre Hospitalier Général
12027 Rodez Cedex 9
France
> Date: Thu, 11 Jun 2009 11:51:57 +0100
> From: [log in to unmask]
> Subject: Re: Vitamin D over requesting
> To: [log in to unmask]
>
> The large literature describing the association of low vitamin D values with disease, morbidity and mortality
> without classic symptoms of D deficiency seems to universally ignore the evidence that vitamin D-binding
> protein, otherwise known as Gc-globulin, is a negative acute phase protein like albumin.
>
> In addition to binding vitamin D Gc-globulin also binds actin, which is released from cells damaged by tissue
> injury, inflammation or sepsis. The complex is then cleared rapidly from the circulation, very low values
> correlating with poor survival (reviewed by Meier et al, Clin Chem 2006;52:1247-1253). So low D values do not
> necessarily indicate D-deficiency.
>
> Brian Payne
Souhaitez vous « être au bureau sans y être » ? Oui je le veux !
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