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High specificity for what? It's reported as elevated in gastric Ca, pancreatic Ca, colorectal Ca, breast Ca, ovarian Ca and doubtless others. Probably therefore only for malignancy (but of course only until proven otherwise). Michael Dr C M Colley Consultant Chemical Pathologist Great Western Hospital Swindon SN3 6BB -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of PD Dr. Michael Steiner Sent: 19 June 2009 17:07 To: [log in to unmask] Subject: CA 72-4 Dear colleagues, CA 72-4 is known for high specificity. However, first-ever slightly elevated CA 72-4 is a troublesome finding. For example, I wonder if 115 U/mL (cut-off 6.9) would (still) be compatible with non-malignant pathology? As ever, sharing collected wisdom is acknowledged. Best regards, Mike -- **************************************** PD Dr. med. Michael Steiner [log in to unmask] Tel: +49-381-7022701 **************************************** Medizinisches Labor Rostock Südring 81, D-18059 Rostock ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ Great Western Hospitals NHS Foundation Trust Great Western Hospital Marlborough Road Swindon SN3 6BB Tel 01793 60 40 20 http://www.gwh.nhs.uk Register to become a member of the Trust at https://www.nhs-membership.co.uk/gwh This message and any files transmitted with it are confidential and intended solely for the individual(s) addressed. If you believe you have received this e-mail in error, disclosing, copying, distributing or retaining this message, or any part of it, is strictly prohibited; please notify the sender immediately and delete it from your system. Any views or opinions presented are solely those of the author and do not necessarily represent those of Great Western Hospitals NHS Foundation Trust. All messages sent by the Trust are checked for viruses but this does not, and cannot, guarantee that a virus has not been transmitted. The Trust accepts no liability for any damage caused by any virus transmitted with this e-mail. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/