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Hi All, (Newbie, so I apologize in advance) So here is my scenario: Single subject, 9 total runs (3 with condition A, 3 with condition B, 3 with condition C) all collected during a single visit. 1st Level Analysis on each run separately. - 1 EV: Simple 20s block design (rArArArA or rBrBrBrB or rCrCrCrC) - 1 Contrast: 1 2nd Level Analysis (here is the quandry) Should I use? Setup 1 (similar to "tripled" t-test" on website but without additional EV for removal of means) EVs: Input Grp EV1 EV2 A1 1 1 1 A2 1 1 1 A3 1 1 1 B1 1 -1 0 B2 1 -1 0 B3 1 -1 0 C1 1 0 -1 C2 1 0 -1 C3 1 0 -1 Contrasts EV1 EV2 A-C 1 2 C-A -1 -2 A-B 2 1 C-B 1 -1 B-A -2 -1 B-C -1 1 A mean 1 1 B mean -1 0 C mean 0 -1 Or should I use setup 2? EVs: Input Grp EV1 EV2 EV3 A1 1 1 0 0 A2 1 1 0 0 A3 1 1 0 0 B1 1 0 1 0 B2 1 0 1 0 B3 1 0 1 0 C1 1 0 0 1 C2 1 0 0 1 C3 1 0 0 1 Contrasts EV1 EV2 EV3 A-C 1 0 -1 C-A -1 0 1 A-B 1 -1 0 C-B 0 -1 1 B-A -1 1 0 B-C 0 1 -1 A mean 1 0 0 B mean 0 1 0 C mean 0 0 1 Or am I missing the boat entirely? I've tried running higher level analysis with both set-ups and the results come out nearly but not exactly identical except for the contrasts to determine condition means. Alternatively, should I run a higher level for each condition separately (single group average) and then feed those into a third level using one of the above setups but with only 3 inputs? Many thanks, Daniel