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Hi Steve, Thank you for your reply! We'll give it a go then. Fingers crossed ;) Cheers, Andries ________________________________ From: FSL - FMRIB's Software Library on behalf of Steve Smith Sent: Sun 5/17/2009 10:59 To: [log in to unmask] Subject: Re: [FSL] denoising T1's prior to VBM Hi - in general we don't recommend pre-de-noising because FAST has an explicit built-in regularisation using an MRF that is design to handle noise.... Cheers. On 15 May 2009, at 14:22, Leij, A.R. van der wrote: > Dear FSL team, > > I'm about to run a VBM analysis. We manually betted a couple of > brains in our set that still contained some skull etc. I was > wondering what the effect would be if we denoised our images prior > to the Fast step in the VBM analysis using Susan? Would this improve > the quality of the VBM set? > > Regards, > > Andries van der Leij --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve ---------------------------------------------------------------------------