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Dear Ariana, > I've been having trouble getting the nonlinear registration to work > when > using MELODIC. This problem occurs when I try to use multi-session > temporal > concatenation, and only occurs when I turn on the non-linear > registration > option. The analysis works fine using the regular registration, but > I get > error messages when using non-linear for the same analysis and same > files. > > I understand this is possibly due to me not having the full > structural files, > but these are not available. I only have the 4D scans available. when you say "4D scans", do you by that mean your EPI scans? I am afraid that you cannot use non-linear registration base only on these. Primarily because we don't have an EPI template in standard space (unlike e.g. flirt, fnirt needs a template with similar-ish contrast to the image you want to register). Even if we were to supply an EPI template it is often the case that these contain so little/poor structural information that the non-linear registration would have little to work with. So, I am afraid that my best advice to you is to be happy with the linear registration. Good Luck Jesper