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Dear all, Quite a few crystallisation conditions in the screens feature 'sodium/potassium phosphate'. I'm curious to know why such a Na/K mix is there. As the pH is mostly determined by the (H2PO4)- to (HPO4)2- ratio, is there such a need to have both cations? If so, is the Na to K ratio important? On the more practical side of things, if you want to explore an initial hit based on sodium/potassium phosphate, how would you go about it - e.g. what phosphate buffers would you make and at what ratio would you mix them? Thanks in advance, Geoffrey Kong