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Hi Brahim, Yes it is possible to adjust spm_preproc, spm_prep2sn and spm_preproc_write in order to segment and write brain classes with additional priors... I will send you later a script that you can adapt to your particular dataset/modality for lesion identification... I hope this helps, Mohamed Brahim HAMADICHAREF wrote: > Anyone has modified the spm_segment to try the lesion identification > methodology > as described in Seghier's NeuroImage paper > (doi:10.1016/j.neuroimage.2008.03.028 > <http://dx.doi.org/10.1016/j.neuroimage.2008.03.028>) ? > > Regards > > Dr Brahim HAMADICHAREF > > > > ------------------------------------------------------------------------ > Chat online and in real-time with friends and family! Windows Live > Messenger <http://get.live.com/messenger/overview>